الفهرس 
Immediate implant surrounded by mixture of plasma rich fibrin, xenograft with melatonin granules vs. immediate implant surrounded by plasma rich fibrin and xenograft at premolar regio
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Abstract
Aim of study: The aim of this double-blinded randomized clinical trial was to evaluate the effect of mixing melatonin combined with xenograft and PRF versus xenograft and PRF alone when used around immediate implants inserted in the upper premolar region on the radiographic bone density, marginal bone loss as well as postoperative pain. Methods: The present study included 16 patients (7 males and 9 females, aged 20 to 45 years) suffering from at least one non-restorable tooth in the premolar zone that needed to be extracted. Results: Regarding radiographic bone density, from baseline to 3 month there was a statistically significant reduction in bone density in both groups. from 3 to 6-month, control group showed a statistically significant reduction in bone density while study group showed a non-statistically significant increase in bone density. Regarding marginal bone loss, both groups showed a statistically significant increase in bone loss throughout the study period with no statistically significant difference between them. Conclusion: Both treatment modalities (xenograft + PRF or xenograft + PRF mixed with melatonin) failed to minimize marginal bone loss at 6-month post-immediate implant placement