الفهرس 
Fecal matrix metalloprotease-9 as a proposed biomarker for detecting activity of inflammatory bowel disease in pediatric patients
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Abstract
Introduction and background: Matrix metalloproteinase- (MMP-) 9 is one of the main metalloproteinases reported to be involved in triggering of angiogenic switch in the course of inflammatory bowel diseases (IBD). We aimed to evaluate the accuracy of fecal MMP-9 enzyme in detecting activity in IBD compared to PCDAI/ PUCAI scores. Methods: Forty one pediatric patients of both sexes with confirmed diagnosis ofIBD aged from I year up to 18 years, were included. Following up at pediatric gastroentrology clinic of Cairo university new children hospital, during period from May To November 2019. Diagnosis was based on combination of history taking , clinical examination , endoscopicfindings,biopsyandhistopathalogical examination as well as imaging procedures. A control group consisted of 40 age- and sex-matched healthy children. Results: Mild activity was identified in 61.9% of ulcerative colitis (UC) patients and 75% amongCrohn{u2019}s disease (CD) patients. The PUCAI values ranged from 5 to 50 with a mean of 21.9 (±14.36 SD), while the PCDAI values ranged from 10 to 35 with a mean of 24.86 (±7.28 SD). The mean hemoglobin (Hb), hematocrit ( Hct), and white blood cell count (WBCs) among IBD groups were significantly different from the control group. The mean Fecal MMP9 among IBD groups was significantly higher as compared to the control group. A statisticallysignificant positiveand high correlation (r = 0.80; p-value < 0.001) was found between the Fecal MMP9 and UC{u2019}s disease activity and with CD{u2019}s disease activity. There was a significantly negative correlation between fecal MMP9 and Hct in the control and UC groups (with much stronger correlation in UC)