الفهرس 
Formulation and evaluation of nanosizede thosomes for improved transdermal drug delivery
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Abstract
Inflammation is a defense response against infection and injury that localizes or eliminates the injurious agent and removes the damaged tissues to allow body recovery and healing.The regulatory mechanisms of the inflammatory response may be defected, impaired or damaged by an inappropriate autoimmuneand therefore, they losetheir ability. Blocking the inflammatory signaling pathways by using anti-inflammatory drugs is the way to manage inflammation progress.Mometasone Furoate (MF) is an effective and well-tolerated Corticosteroids with greater anti-inflammatory, anti-pruritic and vasoconstrictor activities.Synthetic Corticosteroids are the main treatment for different types of arthritis such as psoriatic arthritis, rheumatoid arthritis, osteoarthritis, andjuvenile idiopathic arthritis. Althoughcorticosteroids have a potent anti-inflammatory effect,their systemic administration is usually associated with different adverse effects. Therefore, the development of a delivery system with more targeting properties could reduce these effects.Transdermal delivery of corticosteroids provides an alternative non-invasive way for drug administration with avoidance of undesirable effects including first-pass metabolism, fluctuation of drug concentration in plasma, and overdose chances.The main challenge against transdermal drug delivery is the outmost layer of skin stratum corneum that acts as a low permeable barrier opposing drug passage. To overcome this problem, many drug delivery systems were developed to carry drugs deeply across the skin layers