الفهرس 
Expression of BCL2L12 and LIPOCALIN 2 in adult patient with acute myeloid leukemia and correlation with clinical response
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Abstract
Acute myeloid leukemia (AML) is a malignancy arising within the bone marrow (BM), in which leukemic cells proliferate uncontrollably in association with a disruption of normal hematopoiesis (AML is a heterogeneous group of diseases all characterized by uncontrollable proliferation of hematopoietic progenitor cells with arrest of maturation .The development of human Acute Non Lymphoblastic Leukemia ”ANLL” (leukemogenesis) is a multistep process that results in blocked differentiation, increased proliferation and inhibition of apoptosis. This appears due to the involvement of multiple genetic events that give rise to the overt leukemia (genetic factors) also, the activation or inappropriate expression of surface membrane haematopoietic growth factors.AML has a great variability in the pathogenesis. It requires the cooperation between at least two classes of gene mutations The Lipoclin (NGAL) (LCN2) complex is found in blood tumor cells from patients with ALL, AML and CLL types of leukemia. Over expression of free NGAL is observed in blood cells from patients with all types of leukemia