الفهرس 
Title : Treatment outcome & prognostic factors of thymic gland tumors, NCI experience
ContentsOnly 14 pages are availabe for public view
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Abstract
Background: Thymoma and thymic carcinoma are uncommon thoracic tumors. However, they are the most common tumors in the anterior mediastinal region accounting for one third of mediastinal lesions in Europe. No incidence rates were published in the Egyptian data registry though. Treatment of patients with thymoma and thymic carcinoma is challenging for oncologists, owning to the low incidence of the disease and the poor level of evidence for different treatment modalities. Aim of the work: To analyze the treatment outcome and different prognostic factors of thymoma and thymic carcinoma that presented to NCI {u2013} Cairo University during the period between years 2005-2018 Patients and methods: This is a retrospective study involving 50 patients with pathologically proven thymoma and thymic carcinoma, who presented to the National Cancer Institute, Cairo University during the period from January 2005 to May 2018. Data was retrieved from the patients{u2019} medical records. The collected data included the patients{u2019} characteristics, treatment details and patient status at last follow up. Results & conclusion: Patients who underwent surgical intervention had statisitically significant better DFS, Local Control and OS. Post-Operative Radiotherapy improved OS and Local Control. Older age and late stage at presentation were associated with less treatment benefit. Thymic epithelial tumors showed better disease prognosis vs thymic carcinoma. Dose escalation above 50 Gy did not improve prognostic parameters. Larger studies could shed more light on the optimal roles and types of treatment for thymoma and thymic carcinoma