الفهرس 
Formulation and clinical evaluation of certain antihistaminic drug in topical preparations
SummeryOnly 14 pages are availabe for public view
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Abstract
Micro and nano-particles systems are examples of delivery systems constantly in development. These systems have increased drug loading capacities and controlled release of their contents depending on the release pattern needed for a specific compound. They have many advantages making them ideal for topical application such as small particle size, large surface area enhancing skin permeation. Topical formulations are applied at the skin surface and readily penetrated into the stratum corneum resulting in fast action. Presently, there are very few studies on cetirizine hydrochloride microemulsion topically nevertheless, this study has been able to overcome these hindrances and to successfully establish a prescription method for the formulation of microemulsions and investigate it as a carrier for cetirizine hydrochloride and formulate a topical gel. ME could facilitate transport of both hydrophilic and lipophilic compounds (Rossi et al .2017). The effect of using different surfactant, cosurfactant and oils was studied to ensure the stability of the prepared microemulsion and its effect on release kinetics from cetirizine hydrochloride ME. It was formulated in topical gel to decrease the most commonly reported adverse effects during oral therapy and improved the permeation, leading to increase skin hydration and improve bioavailability By developing an optimized formulation of cetirizine hydrochloride ME drug in different systems and optimization was done by 32 factorial designs combined with desirability function, to minimize the size of the particles of the drug using design expert 11.1.0.1 software (Stat Ease, Inc., USA) was used to determine the significance and the effects of each variables and their interactions, and develop a topical microemulsion gel to improve its skin permeability and therefore antihistaminic efficiency.The oils were chosen according to drug solubility on them, surfactant and co-surfactant chosen according to their solubilizing capacity for both oil and drug.Phase diagram constructed to determine the microemulsion region