الفهرس 
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Abstract
The present study aimed to investigate the possible effects of Silybum marianum L. seed extract on obesity and other related complications in rats. Ethanol extract from Silybum marianum (SMEE) seeds was used. 36 male rats were randomly divided into six equal groups.
group 1: normal control, normal mice with normal feed;
group 2: Control model, obese mice with normal forage without intervention; Groups 3 to 6: obese mice with regular forage, intervention groups using SMEE of 150, 300, 450, and 600 mg/kg body weight/day by oral gavage for 8 consecutive weeks. Changes in the levels of lipid components and liver function in blood samples after the SMEE intervention were analyzed. The decrease in body weight occurred during the first 4 weeks of the SMEE intervention and the levels of blood lipids (TGs, TC, and LDL-c) in obese mice in the SMEE groups were significantly decreased at 8 weeks compared to the model control group. Moreover, it was also found that SMEE intervention significantly enhanced liver function in obese mice. This study may indicate that SMEE intervention can provide a beneficial effect with regard to the prevention and early treatment of obesity. It is likely that the anti-obesity effects of SMEE can be attributed to several mechanisms such as its.