الفهرس 
General introductionOnly 14 pages are availabe for public view
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Abstract
The efficacy of orally consumed drugs is limited by their bioavailability. The low oral bioavailability is attributed to poor aqueous solubility, poor permeation through gastrointestinal membrane due to inappropriate partition coefficient, pre-systemic metabolism, drug degradation in gastrointestinal tract or intestinal efflux via P-glycoprotin. Various strategies have been used to improve dissolution rate, solubility, permeability and hence the oral bioavailability. Currently, nanotechnology commonly employed as promising strategy for enhancing oral bioavailability. The performance of nanostructures depends on their specification which can be modulated depending on the composition and surface morphology. Thus the aim of this thesis was investigating different nanosystems as effective tool for oral delivery of anti-parasitic drugs with emphasis on the effect of surface modification on this aspect.