الفهرس 
Heterocyclic compoundsOnly 14 pages are availabe for public view
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Abstract
Heterocyclic compounds are the major and significant class of compounds as heterocyclic moieties present in the structures of more than 75% of the top two hundred branded drugs. Heterocycles are one of the most important topics for pharmaceutical analysts. The present thesis is devoted for the development and validation of new methods for the analysis of some pharmaceutical compounds containing heterocyclic rings, namely: Eplerenone (EPL), Trimetazidine dihydrochloride (TMZ), Amoxicillin (AMX), Pantoprazole sodium sesquihydrate (PAN) and Levofloxacin hemihydrate (LVX) either in their pharmaceutical preparations or in human plasma. There have been some reported methods for determining these drugs. But even so, there is still a need to develop innovative, efficient, more simple, cost-effective, and accurate analytical methods for their determination. Different analytical techniques were adopted for determination of the studied compounds. A water-soluble and highly stable nitrogen and sulfur co-doped carbon quantum dots (N,S-CQDs) were synthesized and used as efficient fluorescent sensors for determination of each of EPL and TMZ. These QDs were used for the sensitive and selective sensing of EPL and TMZ as simple and efficient fluorescent sensors. Also, through these QDs, EPL and TMZ could be determined successfully in their tablets and human plasma samples. The binding of small molecular drugs with human serum albumin (HSA) has a crucial influence on their pharmacokinetics. The binding interaction between EPL and TMZ with HSA was investigated using multispectroscopic techniques for the first time. These techniques include UV-Vis spectroscopy, Fourier Transform Infrared (FT-IR), native fluorescence spectroscopy, synchronous fluorescence spectroscopy and molecular docking approach. Additionally, a novel and environment friendly reversedphase HPLC-UV method for simultaneous estimation of Co administered (Amoxicillin, Pantoprazole, and Levofloxacin) mixture as an effective combination therapy for Helicobacter pylori infections. This is thought to be the first HPLC method for determining such ternary mixtures. Unlike standard methodology, the developed method was optimized through the use of an analytical quality by design approach. Furthermore, greenness profile of the developed method was evaluated using two greenness assessment tools: the Green Analytical Procedure Index (GAPI) and analytical Eco-Scale guidelines. The principles as well as the experimental parameters of the proposed methods were studied, discussed and explained. The data given were statistically analyzed. The validation criteria of the developed methods were thoroughly investigated. The developed methods can be used in quality control laboratories in pharmaceutical companies and bioequivalence centers for routine analysis of the investigated compounds. The thesis consists of four main parts including 304 references, 33 tables, 43 figures and ends with Arabic summary.