الفهرس 
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Abstract
This study aimed to investigate the effects of Artemisia annua and Spirulina platensis on growth parameters, cellular-mediated and humoral-mediated immune response against some viral diseases, lipid peroxidation products, and antioxidant indices in broilers.
Our study was carried out on one-day old 150 cobb chicks were randomly allocated into six groups (25 chicks per group) as the following:
Group-1: healthy normal chicks fed starter and basal diet without vaccination.
Group-2: healthy normal chicks fed starter and basal diet and subjected to vaccination program.
Group-3: healthy normal chicks fed starter and basal diet without vaccination and given Artemisia annua powder extract 100 mg/liter in drinking water adlibitum.
Group-4: healthy normal chicks fed starter and basal diet, subjected to vaccination program and given Artemisia annua powder extract 100 mg/liter in drinking water adlibitum.
Group-5: healthy normal chicks fed starter and basal diet without vaccination and given Spirulina platensis powder extract 100 mg/liter in drinking water adlibitum.
Group-6: healthy normal chicks fed starter and basal diet, subjected to vaccination program and given Spirulina platensis powder extract 100 mg/liter in drinking water adlibitum.
The blood samples were taken from all groups by slaughtering at 1 day old and from wing vein at 14, 24, 35th day and the tissues (thymus, spleen, bursa of Fabricius ) were taken at the end of experiment.
Results of the present study revealed the following:
1. Artemisia annua and Spirulina platensis supplementation have positive effects on final body weight and body weight gain when compared with the control.
2. supplementation with Artemisia annua and Spirulina platensis non-significantly increased the antibody titer against the studied viruses in the vaccinated groups compared to vaccinated untreated group. While supplementation with Artemisia annua and Spirulina platensis in unvaccinated groups showed significantly decreased antibody titer compared to vaccinated untreated group.
3. Treatment with Artemisia annua and Spirulina platensis significantly increased the lymphocyte differentiation clusters in the spleen, thymus, and bursa in all treated groups either vaccinated or not with highest values observed in the vaccinated treated groups.
4. supplementation with Artemisia annua and Spirulina platensis non-significantly decreased the lipid peroxidation in the spleen tissue compared to control.
5. Supplementation with Artemisia annua and Spirulina platensis significantly elevated the level of NRF2, total glutathione, and reduced glutathione along with decline in the concentration of oxidized glutathione in spleen tissue compared to control untreated group.