الفهرس 
Sickle Cell DiseaseOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Sickle cell disease (SCD) is a group of typically inherited red blood cell disorders resulting from presence of mutated form of Hemoglobin (Hb); HbS, People with SCD have abnormal Hb, called Hb S or sickle Hb, in their red blood cells (RBCs).The most common form of SCD is homozygous HbS disease, an autosomal recessive disorder.
Objective: To detect the alloimmune markers in sickle cell disease and their effect on disease severity and outcome.
Patients and Methods: This study was a cross sectional prospective study. It included 50 children with sickle cell disease on regular follow up attended the Hematology Unit, Pediatrics Hospital, Ain-Shams University. The study was conducted at the Hematology Unit of Pediatrics Hospital, Ain-Shams University
Results: Our results revealed that pre-transfusion Hb level was 73± 1.4 gm/dl and HbS was 61.86± 17.53%. Also, serum ferritin level among the studied patients was 3611 ng/ml (Range 1731-5432 ng/ml).
Conclusion: Alloimmunization can be found frequently in sickle cell disease patients especially the chronically transfused patients.