الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Erectile dysfunction is affects considerably and negatively the men and their partners. Its prevalence increases with age and has been associated with several factors including hormonal changes and subclinical inflammation among several other causes. Therefore, appropriate investigation of underlying causes and their correction in addition to current treatment strategies may improve the erectile function of the men with ED.
Induction and maintenance of erection is orchestrated by several neuroendocrine factors and penile vascular endothelium is key in the process. Vascular and neural integrity in a good hormonal milieu are prerequisite for the normal erectile function. Penile color duplex Doppler ultrasound along with vasoactive agent is used to evaluate the vascular status in patients with suspected vasculogenic ED. Classification of vasculogenic ED is made by measuring peak systolic velocity (PSV), end diastolic velocity and resistive index (PSV-EDV/ PSV)
Endothelial dysfunction often associated with subclinical inflammation has been associated with rise of certain inflammatory markers including CRP, NLR & PLR among others. Inflammation has been recognized in development and progression of atherosclerosis.
Testosterone deficiency is linked to decreased erectile function, and levels of testosterone are inversely related to the severity of erectile dysfunction. Multifactorial pathologies can cause erectile dysfunction. Estrogen and prolactin affect negatively the erectile function.
Our study aimed to assess the significance of inflammation and hormonal profile among patients with ED and comparison with Doppler ultrasound in patients with ED.
This is a case control study that was carried out at Faculty of Medicine, University of Alexandria, on 25 patients complaining of erectile dysfunction and 15 healthy age matched controls. All study subjects undergone history taking, physical examination, blood sampling and patients with ED filled IIEF-5 questionnaire and underwent pharmacopenile Doppler ultrasound scanning at same private institution. All blood samples were analyzed at one laboratory.