الفهرس 
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Abstract
Infertility is becoming a growing global public health issue according to the World Health Organization, which is warning about the relevant impact that this condition has on society, it has been reported that about 50 million couples worldwide may be affected, with male infertility.
Spermatogenesis is a complex process that involves genes, hormones and other factors whose expression during different stages is strictly regulated
Recently, alterations in the level of thyroid in both human and animal models have been linked to many forms of disease.
Altered thyroid state is associated with abnormalities in sexual functions and impaired fertility in humans and rats.
ROS are detrimental to spermsurvival and function due to its adverse effects on spermmembrane and genetic material.
Hyperthyroidism induction caused a significant reduction in SOD and CAT activity and a significant increase in GPx activities.
Supplementation of vitamin E alone as an antioxidant in hyperthyroid rats which was treated by carbimazole enhanced the active spermatogenesis in these rats.
The main purpose of the present study was to assess the molecular influence of experimental hyperthyroidism-induced testicular injury on adult male albino rats’ testes and to evaluate the possible biochemical and molecular therapeutic mechanisms underlying the effects of CBZ alone and in combination with vitamin E. Additionally, the adjuvant therapeutic effects of vitamin E on the human equivalent therapeutic regimens of CBZ-induced injurious testicular affection in an attempt to detect the role of vitamin E against ROS.
This was an experimental study carried out in the andrology and pharmacology department in Suez Canal University, Ismailia Egypt), on 64 ratsdivided inti 8 groups.
The main results of the study revealed that:
Altered thyroid state has negative effects on testicular functions.
Analysis of the data shown that supplementation of vitamin E improve testicular functions in hyperthyroid rats treated by carbimazole.
Based on our findings we recommend for further studies on larger sample size to emphasize our conclusion.