الفهرس 
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Abstract
SUMMARY
Magnetic resonance imaging (MRI) is an imaging technique which is used to visualize the internal structure and function of the body when not specified by other modalities. The inherent advantages of high contrast resolution, lack of ionizing radiation, as well as usage of advanced sequences and MR techniques renders it a favored modality.
Diffusion-weighted imaging (DWI) is a new magnetic resonance imaging (MRI) technique that provides imaging of diffusion in biological tissues.
Screening, accurate detection, and characterization of focal hepatic lesions are important for planning treatment of malignant hepatic lesions.
Diffusion-weighted imaging (DWI) has been reported to be useful for the early detection of small focal hepatic lesions. Moreover, DWI offers the possibility to obtain criteria for lesion characterization without the need for contrast agent administration by quantifying diffusion effects via apparent diffusion coefficient (ADC) measurements, with better results compared with those of conventional MR imaging.
Several studies have reported that ADC can contribute to the differentiation between benign and malignant lesions. The concomitant use with contrast enhancement criteria increases the accuracy of detection and characterization.
The aim of the present study was to investigate the usefulness of ADC ratio of a solid liver lesion to liver parenchyma to discriminate between benign and malignant lesions.
This was a cross sectional study conducted on all patients with hepatic solid focal lesion (benign or malignant) on cirrhotic or normal liver parenchyma, starting from 10-2019 to 4-2020. All patients were subjected to: Full history taking including, Radiological investigations, and Laboratory investigations.
The main results of the study revealed that:
There was significant difference between benign and malignant group as regards age (46.84 ± 15.46 vs 57.84 ± 10.75, p = 0.006).
There was significant difference between benign and malignant group as regards S. creatinine and AFP(0.89 ± 0.26vs 1.24 ± 0.22 and 2.31 ± 2.05 vs 207.38 ± 256.60, p<0.001).
There was significant difference between benign and malignant group as regards ADC lesion, ADC liver and ADC ratio.
The calculated area under the ROC curve for to discriminate malignant from benign was 0.938 (95 % CI 0.869, 1.006), with a sensitivity of 84 % and a specificity of 100%, using a cut-off ADC lesion value of 1191.
The calculated area under the ROC curve for to discriminate malignant from benign was 0.973 (95 % CI 0.936, 1.010), with a sensitivity of 84 % and a specificity of 100%, using a cut-off ADC ratio value of 0.9857.
There was significant difference between benign and malignant group as regards cirrhosis and Diagnosis.
Based on our results we recommend for further studies on larger patients and longer period of follow up to emphasize our conclusion.