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Abstract Background: In recent years, much evidence showed that vitamin D3 deficiency could be related to several chronic diseases such as diabetes, cardiovascular disease. So, the goal of the study is assess the effect of cholecalciferol on hypercholesterolemic rats at different levels of supplementation vitamin D3. Methods: 56 albino rats were in coporated as follows: (G1) The first group ( 8 rats) were fed a basal diet, kept as negative group. (G2)The second main group (48 rats) was received for 8 weeks (diet containing 10% sucrose, 0.25% bile salts, 1% cholesterol) to induce hypercholesterolemia in rats. for 8 weeks and divided into 6 subgroups (8rats each): the after 1st group fed on hypercholesterolemic diet as a positive control group, from ( 2 : 7 st) groups fed on hypercholesterolemic diet and supplemented with vitamin D3 at different levels (0.5, 0.1, 1.5, 2, 2.5 mcg /kg diet) . Results: The positive control group of hypercholesterolemic recorded a highly remarkable increase in serum CHO,TG,LDL,VLDL,HBA1c , tissue malondialdehyde ( MDA ) and a decrease in serum HDL, Vit D3 and in tissue SOD and GSH when compared with negative control group .But when vit D3 administered at different levels ,there were significant improvements in all lipid parameters , antioxidant enzymes and . The best improvement was found in vit D3 at level 2 mcg when compared with the (+ve )group. The pathological examination of the liver confirmed these results . Conclusion: VitD3 at different levels showed an excellent effect on lipid profile at the studied levels. More studies are needed to discover therapeutic effects of vitamin at different levels. Key words: cholecalciferol - hypercholesterolemia - oxidative stress, HDL – MDA_HBA1C_ Rats |