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العنوان
Effect of Cholecalciferol on Hypercholesterolemic Rats /
المؤلف
Ali، Zeinab Abd Eladl Ismail.
هيئة الاعداد
باحث / زينب عبدالعدل اسماعيل علي
مشرف / مني عبد الستار عبدالباسط
مشرف / داليا رفعت حسن
مناقش / داليا رفعت حسن
الموضوع
qrmak
تاريخ النشر
2022
عدد الصفحات
151 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
اقتصاد منزلي
تاريخ الإجازة
8/3/2022
مكان الإجازة
جامعة الفيوم - كلية التربية النوعية - قسم الاقتصاد المنزلي
الفهرس
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Abstract

Background: In recent years, much evidence showed that vitamin
D3 deficiency could be related to several chronic diseases such as
diabetes, cardiovascular disease. So, the goal of the study is assess
the effect of cholecalciferol on hypercholesterolemic rats at different
levels of supplementation vitamin D3. Methods: 56 albino rats were
in coporated as follows: (G1) The first group ( 8 rats) were fed a basal
diet, kept as negative group. (G2)The second main group (48 rats)
was received for 8 weeks (diet containing 10% sucrose, 0.25% bile
salts, 1% cholesterol) to induce hypercholesterolemia in rats. for 8
weeks and divided into 6 subgroups (8rats each): the after 1st group
fed on hypercholesterolemic diet as a positive control group, from (
2 : 7 st) groups fed on hypercholesterolemic diet and supplemented
with vitamin D3 at different levels (0.5, 0.1, 1.5, 2, 2.5 mcg /kg diet) .
Results: The positive control group of hypercholesterolemic recorded
a highly remarkable increase in serum CHO,TG,LDL,VLDL,HBA1c ,
tissue malondialdehyde ( MDA ) and a decrease in serum HDL, Vit D3
and in tissue SOD and GSH when compared with negative control
group .But when vit D3 administered at different levels ,there were
significant improvements in all lipid parameters , antioxidant
enzymes and . The best improvement was found in vit D3 at level 2
mcg when compared with the (+ve )group. The pathological
examination of the liver confirmed these results . Conclusion: VitD3
at different levels showed an excellent effect on lipid profile at the
studied levels. More studies are needed to discover therapeutic
effects of vitamin at different levels. Key words: cholecalciferol -
hypercholesterolemia - oxidative stress, HDL – MDA_HBA1C_ Rats