الفهرس 
PARKINSON’S DISEASEOnly 14 pages are availabe for public view
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Abstract
Background: Impulse control disorders in PD represent the major non-motor complications of dopaminergic treatment and Levodopa-induced dyskinesias represent the other essential motor complications of the same treatment.Both of them are common and debilitating. They my coexist and an association has been proposed.
Objective: Aim of the study is to study the association between levodopa- induced dyskinesia and impulse control disorders in PD (correlation between motor and non-motor hyperdopaminergic state).
Patients and Methods: This cross-sectional study was conducted on 30 patients with Parkinson’s disease attending the movement disorders outpatient clinic at Ain Shams University Hospital. Each patient underwent a comprehensive assessment including MDS-UPDRS part III and part IV, Hoehn and Yahr rating (H&Y), Unified Dyskinesia Rating scale(UDysRs), Questionnaire for Impulsive Compulsive Disorders in Parkinson’s Disease Rating Scale(QUIP-Rs), PD NMS questionnaire, Montreal Cognitive Assessment Arabic version(Arabic MoCA), Beck depression inventory(BDI) and Parkinson’s anxiety scale(PAS).
Results: This study didn’t show a significant correlation between Levodopa-induced dyskinesias and impulse control disorders in PD patients. Additionally, a fair correlation is demonstrated between the Unified dyskinesia rating scale and scores of levodopa equivalent daily dose (LEED), disease duration, levodopa duration and MDS-UPDRS part 3 while there was no significant correlation between the Unified dyskinesia rating scale and both age and MOCA scale results. Similarly, there is no significant correlation between QUIP-Rs regarding age, LEED, disease duration, levodopa duration, MDS-UPDRS part 3, PD NMSS, BDI and PAS.
Conclusion: 60% of our Parkinson’s disease patients with dyskinesia have impulse control disorders which is clinically significant. However there was no correlation between total scores of Unified Dyskinesia Rating scale and total scores of Questionnaire for Impulsive Compulsive Disorders Rating scale. There is a fair correlation between Unified Dyskinesia Rating scale total score and scores of levodopa equivalent daily dose, disease duration, levodopa duration and MDS-UPDRS part 3.