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Abstract Background: Interferential current stimulation may increase the blood flow when applied on both sympathetic dorso-lumber and sacral parasympathetic chain. This study was conducted to determine vasodilatation effect of interferential current therapy (IFC) when applied on dorso-lumber sympathetic chain or on applied on sacral parasympathetic chain. Material and method; Thirty healthy subjects participated in this study; their ages ranged from 20-35 years, they were selected from employee of Elkasr Elaini hospital at summer 2014. They were randomly assigned into two study group of equal number; group (A) received interferential stimulation on the sympathetic chain, while group (B) received interferential stimulation on parasympathetic chain. Blood flow in lower limbs (right and left ) was evaluated by duplex doppler ultrasound (DDU) pre, immediately post stimulation and 30 minutes post IF stimulation. Results: revealed that there were no significant differences in the measured variables within groups regarding the measurement times and lower limbs sides (p >0.05) and also there was no significant difference between group (p >0.05). Conclusion: from the obtained results of this study, it could be concluded that IFC stimulation of the dorso- lumber sympathetic chain and sacral parasympathetic chain did not have effect on blood flow |