الفهرس 
ERUM ZINC AND COPPER LEVEL IN EGYPTIAN CHILDREN WITH BETA- THALASSEMIA MAJOR
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Abstract
Background : In patients with thalassemia major erythrocyte transfusions induce iron overload and tissue damage, in addition to the increased hemolysis, these elevate oxidative stress resulting in over utilization of minerals required for antioxidant enzymes. Iron chelators may remove minerals from the body making them more at risk for mineral deficiency. Objectives : To determine levels of serum zinc and copper in Egyptian children with Ý-thalassemia major on two different oral iron chelators and its relation to clinical and routine laboratory parameters. Methods: This cross sectional study aimed at investigating serum zinc and copper levels in Ý thalassemia major (BTM) Egyptian children on oral iron chelators. 60 patients were enrolled, 30 on each chelator (31 males and 29 females) attending Hematology Clinic of Cairo University Children Hospital aged 2.5-17.9 years. 30 sex and age matched subjects were enrolled as a control group. They were subjected to history taking, clinical examination and laboratory investigations including serum zinc and copper.Results: Zinc was deficient in 8 patients (4 males and 4 females), 3 of them on deferasirox and the other 5 on deferiproe therapy. Copper was high in 21patients (10 males and 11 females), 13 of them on deferasirox and 8 on deferiprone therapy. Zinc and copper levels were not significantly correlated with the type of oral chelator, chelator duration or adherence, serum ferritin, dietary zinc and copper intake, gender, weight or body mass index