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Abstract Fatty liver disease is one of the most dominant chronic liver diseases that disperses among children with different ages’ and adults. Non-alcoholic fatty liver disease (NAFLD) includes a wide spectrum of liver injury stages: steatosis, steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma. No drugs can be used to treat NAFLD; only some clinical recommendations must be followed for management of NAFLD. Functional foods including fermented dairy products provide various healthy benefits in addition to their higher nutritional value.Therefore, the current study aimed to evaluate the protective effect of fermented camel milk (FCM) on progression of NAFLD induced by a high fat diet and high fructose syrup (HFDHFr) in rats. The present study included evaluation the effect of microencapsulation of some probiotic strains combined with or without plant extract on their viability under simulated gastrointestinal conditions (SGC) as well as the properties of the resultant FCM during storage at 4{u00B0}C for 21 days. In addition to, evaluate the effect of the resultant FCM on different biochemical markers of rats’ serum that feeding on HFDHFr, as well as histological examination |