الفهرس | Only 14 pages are availabe for public view |
Abstract Mesenchymal stem cells (MSCs) with a capacity of self-renewal and multi-lineage differentiation have attracted worldwide attention during the past decade as progenitor cell source for tissue engineering and regeneration. MSCs were first identified in aspirates of adult bone marrow. They developed clonogenic clusters of adherent fibroblastic colony-forming units with the potential to undergo extensive proliferation in vitro and to differentiate into different stromal cell lineages. Since then, bone marrow was the most utilized source of MSCs; however, there was a need to isolate MSCs from accessible tissues with less surgical trauma. Recently, stem cells from dental tissues have provided that alternate source of MSCs with characterization of stem cells within the dental pulp stem cells (DPSCs), periodontal ligament stem cells (PDLSCs), stem cells from human exfoliated deciduous teeth (SHED), dental follicle progenitor cells (DFPCs), stem cells from apical papilla (SCAP), oral periosteum stem cells (OPSCs) and recently from gingival connective tissue (GMSCs), however there is still limited evidence regarding the capacity of dental MSCs for bone regeneration |