الفهرس 
Renal doppler ultrasound in acute kidney injury in hypoxic neonates
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Abstract
Background: Asphyxia is an important cause of morbidity and mortality among neonates. As kidneys are very sensitive to oxygen deprivation, renal insufficiency may occur within 24 hours of a hypoxic ischemic episode, so early recognition of acute kidney injury (AKI) is important in neonates with hypoxic ischemic encephalopathy (HIE). Aim of the work: To assess the role of renal Doppler ultrasound and increment in serum creatinine levels to detect AKI in hypoxic neonates. Methods:80 full-term neonates, 50 neonates diagnosed clinically as hypoxic ischemic encephalopathy (HIE) (patient group) and 30 health neonates (control group),were studied regarding their history, physical examination including Sarnat staging, serum creatinine rise, BUN, urine output estimation, renal and cranial Doppler ultrasound. AKI was diagnosed according to criteria of neonatal Kidney Disease Improving Global Outcome (KDIGO). Results: 68% of hypoxic neonates developed AKI with predominance of non-oliguric type (42 %). Renal blood flow velocities (PSV, EDV, AT) were significantly decreased (P<0.0001) and renal RI was significantly increased (P<0.0001) in hypoxic neonates than controls. Renal echogenicity was significantly increased in hypoxic neonates with AKI (P<0.0001).Middle cerebral artery resistive index (MCA RI) was significantly increased in cases than controls (P<0.0001)