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العنوان
Assessment of anti-inflammatory effect of ginger on mucositis induced by cetuximab drug in rats :
الناشر
Wegdan Sayed Abdelaziz Taha ,
المؤلف
Wegdan Sayed Abdelaziz Taha
هيئة الاعداد
باحث / Wegdan Sayed Abdelaziz Taha
مشرف / Mona Ezzat Wali
مشرف / Nermine Raouf Amin
مشرف / Sahar Mohamed Emad El Din Riyad
تاريخ النشر
2019
عدد الصفحات
74 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Oral Surgery
تاريخ الإجازة
9/9/2019
مكان الإجازة
جامعة القاهرة - الفم والأسنان - Oral and Maxillofacial Pathology
الفهرس
Only 14 pages are availabe for public view

from 103

from 103

Abstract

Background: Oral mucositis induced by Cetuximab drug is associated with remarkable morbidity or permanent treatment discontinuation and therefore the use of ginger would be beneficial in treatment of mucositis. In this study we aimed to evaluate the effect of Ginger on the inflammatory reaction induced by Cetuximab drug through COX-2 immunoexpression in tongue mucosa of experimental rats. Material and Methods:16 rats and 16 archival blocks were used, divided into 4 groups: a control group (8 archival blocks), Cetuximab group (8 archival blocks), group III (8 rats received Ginger by oral gavage in parallel with Cetuximab) and group IV (8 rats received Ginger by oral gavage one week ahead of Cetuximab). Tongue dissection was performed at euthanization date. Area percent of the immunohistochemical expression of COX-2 was measured by software Leica Qwin 500. Results: COX-2 was expressed in epithelium of Cetuximab group and loss of this expression was found in normal tongue mucosa and Cetuximab + Ginger group. A statistically significant difference in COX-2 expression was present between Cetuximab group and Cetuximab + Ginger group and Ginger one week ahead of Cetuximab group. Conclusion: Ginger administration can reduce inflammation caused by Cetuximab drug in tongue mucosa of rats