الفهرس 
Accuracy of liver function tests in early differentiation of biliary atresia from other causes of medical cholestasis
ABSTRACTOnly 14 pages are availabe for public view
 |  | from | 105 |  |  |
| | | from | 105 | | |
Abstract
Background and aim: Early diagnosis of biliary atresia (BA) is important because the prognosis is closely related to timing of Kasai operation. The overlapping features of BA and other medical causes of cholestasis has posed challenge for diagnosis of BA. The aim of this study was to check the accuracy of liver function tests in early differentiation of BA from other causes of medical cholestasis. Material and methods: This cross-sectional study was conducted at Pediatric Hepatology Unit, Cairo University Pediatric Hospital. It included neonates and infants who presented with cholestasis elevated GGT during the first three months of life over a 6-year period from 2013 to 2018. Patients were divided in two groups (BA and non BA). Results: The study included 140 patients; 70 BA and 70 non BA patients. Clay stools were more significantly common among BA patients than non BA (pvalue {u02C2}0.0001). GGT, GGT/ALT, GGT/AST and total bilirubin were statistically significantly higher in BA than non BA. ROC curves were plotted for those four parameters to determine the best cutoff value for diagnosis of BA. GGT level greater than 706 IU/L showed a sensitivity of 72.9% and specificity of 77.1%, GGT/AST ratio >2.3 had a sensitivity of 84%, specificity 54% GGT/ALT ratio >2.8 had a sensitivity of 91.4% and specificity of 42.9%, and total bilirubin >8.85 had a sensitivity of 74.3% and specificity of 57.1%