الفهرس 
Title : Effect of lactoferrin in treatment of iron deficiency anemia in school age children
AbstractOnly 14 pages are availabe for public view
 |  | from | 146 |  |  |
| | | from | 146 | | |
Abstract
Introduction: Iron deficiency anemia (IDA) is the most common nutritional deficiency complication in school age children resulting in many serious consequences such as delayed physical growth, irreversible alterations of cognitive and behavioral performance. Iron therapy is still the first choice for treatment of IDA but many recent studies demonstrated that lactoferrin was effective in treatment of IDA in pregnant females with less side effects. Aim: The study is aiming at evaluation of the effectiveness of lactoferrin in treatment of IDA in school age children (5-15 years) in comparison with ferrous sulfate, and its associated side effects. Methods: A randomized controlled clinical trial was conducted on two groups for 8 weeks where control group received ferrous sulfate and intervention group received lactoferrin. Each one of 45 children (5-15 years) with IDA attended outpatient clinic of Tammya primary health care center, Fayoum governorate, Egypt. Results: After 8 weeks of receiving medications there was a statistically significant increase in mean serum ferritin, hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) in both groups as follows; the mean ferritin increased from 6.2 og / L to 18.2 og / L in ferrous sulfate group and from 6.2 og / L to 21.1 og / L in lactoferrin group, the mean Hb increased from 10.2 g / dl to 11.2 g / dl in ferrous sulfate group and from 10.3 g / dl to 11.4 g / dl in lactoferrin group, the mean Hct increased from 32.6% to 35.2% in ferrous sulfate group and from 33.3% to 36.9% in lactoferrin group, the mean MCV increased from 72.2 fl to 76.6 fl in ferrous sulfate group and from 73.2 fl to 78.2 fl in lactoferrin group, the mean MCH increased from 22.6pg to 26.1 pg in ferrous sulfate group and from 23.6pg to 27.1 pg in lactoferrin group. No significant difference between ferrous sulfate group and lactoferrin group after treatment in mean of hemoglobin (P value 0.254) while there is a significant difference between ferrous sulfate group and lactoferrin group after treatment in mean of level of ferritin P value 0.01, hematocrit P value 0.001, MCV p value 0.007, MCH p value 0.048