الفهرس 
Title : Detection of the relationship between G6PD deficiency and neonatal sepsis
AbstractOnly 14 pages are availabe for public view
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Abstract
Methodology 100 neonates: 50 neonates with sepsis and 50 healthy neonates as the control group admitted in the Neonatal Intensive Care Units (NICU) at the Cairo University children hospitals and El- Mounira general hospital were included. All neonates were subjected to the following: history taking as regards gestational age, sex, cause of admission, and age and duration of admission at time of enrollment, and the outcome of sepsis, history of maternal fever, foul smelling liquor, prolonged rupture of membranes (>24 hrs.), CBC with emphasis on WBC count, mature and immature neutrophils, lymphocytes, hemoglobin level, platelet count, CRP, blood C&S, quantitative G6PD assay. The primary outcome was identification of G6PD deficiency as a risk factor for neonatal sepsis. The secondary outcomes were detection of any correlation between G6PD assay and determination of cut-off levels below which sepsis occurs, outcome of sepsis in terms of resolution of sepsis and discharge, duration of hospital stay or death. Results The results showed that Percentage of EONS was 20% (10 cases) while LONS was 80% (40 cases). Percentage of confirmed positive blood culture among cases was 84% (42 cases). Rodwell score for sepsis was significantly higher in cases compared to controls. However, the difference between the mean G6PD between cases and controls was not statistically significant (p value 0.846). There were no statistically significant correlations between G6PD and gender, onset of sepsis and causative organisms in positive blood cultures. Conclusions Our study suggested that there is no relationship between G6PD deficiency and neonatal sepsis