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العنوان
Analytical study of some pharmaceutical compounds /
الناشر
Sally Saad Eldin Mahmoud Elmosallamy ,
المؤلف
Sally Saad Eldin Mahmoud Elmosallamy
هيئة الاعداد
باحث / Sally Saad Eldin Mahmoud Elmosallamy
مشرف / Badr Eldean Abd El-Haleam Elzeany
مشرف / Nagiba Yehia Mohamed Hassan
مشرف / Hanan Abd Elmonem Merey
تاريخ النشر
2019
عدد الصفحات
232 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
العلوم الصيدلية
تاريخ الإجازة
11/11/2019
مكان الإجازة
جامعة القاهرة - كلية الصيدلة - Analytical Chemistry
الفهرس
Only 14 pages are availabe for public view

from 297

from 297

Abstract

This thesis is concerned with the analysis of some pharmaceutical compounds in different mixtures. It comprises three parts, part I is about determination of acefylline piperazine and bromhexine hydrochloride in the presence of their degradation products and dosage form excipients (methyl and propylparabens). While part II is about the simultaneous analysis of a binary mixture of camylofin dihyrochloride and analgin in the presence of their degradation products. In addition to Part III which is concerned with the simultaneous analysis of a binary mixture of calcipotriol monohydrate and betamethasone dipropionate in the presences of dosage form excipients (butylated hydroxytoluene and alpha-tocopherol). Various analytical techniques were used for the simultaneous analysis of these mixtures. The applied techniques include spectrophotometry, chemmometry, thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and electrochemistry. The proposed methods were simple, accurate, and reproducible, which would be feasible, and sensitive for the determination of the studied drugs. The proposed methods were validated according to ICH-guidelines