الفهرس 
Title : Childhood ITP: Risk Factors for chronicity and Impact of Different Treatment Protocols on Prognosis
ContantsOnly 14 pages are availabe for public view
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Abstract
Background: No uniform treatment protocols are adopted in chronic Immune thrombocytopena purpura (ITP) patients, due to variable response to each protocol in different subsets of patients. Objective: to describe the clinical characteristics and disease-related complications of chronic ITP among pediatric and adolescent in the Hematology outpatient clinic, Cairo University Pediatric Hospital and to illustrate the current treatment protocols and the clinical and laboratory response to such protocols. Methodology: A cross sectional study that included 43 pediatric and adolescent with chronic ITP. Different treatment lines applied were evaluated as regards the dose and duration of treatment and its adverse events if any. Clinical status during therapy at different time points was analyzed with emphasis on changes in platelet counts, and changes in symptoms and signs. Results: The studied group included 24 (55.8%) males (M/F 1.3), their mean age was 8.91 (± 3.22) and mean age at diagnosis was 6.35 (±3.1) years. Only 6 patients had complications in the form of cushinoid syndrome in 5 (11.6%) and retinal hemorrhage in 1 case (2.3%). Patient received different lines of treatment, recorded in the last 6 months, ranging from no treatment to 4 lines of treatment. Currently, 30 (69.8%) patients are controlled and 13 (30.2%) are still uncontrolled and scheduled to add a second line or to try other lines till control, six cases (14%) are in complete remission and stopped treatment