الفهرس 
Title : Potentiometric determination of levofloxacin in biological fluids and some of its pharmaceutical compounds
AbstractOnly 14 pages are availabe for public view
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Abstract
Potentiometric sensors were developed for the determination of levofloxacin using polyvinyl chloride (PVC) membrane electrodes, Carbon Paste Electrodes (CPEs), Modified Carbon Paste Electrodes (MCPEs) and Screen Printed Electrodes (SPEs) based on the ionexchangers of levofloxacin with phosphomolybdic acid (LVF3-PM) and sodium tetraphenylborate (LVF-TPB) as the electroactive species. The different sensors were fully characterized and optimized in terms of composition, pH effect, selectivity, response and life times. pH was found to be the key factor in determining the ratio of the different species that can exist in the medium (zwitterionic, monocationic, dicationic, anionic and neutral), and accordingly, it is the controller of the electrochemical performance. The different sensors showed reliable reversibility and high selectivity for levofloxacin over several inorganic ions and sugars. The prepared sensors were applied for the determination of the levofloxacin in its pure form, pharmaceutical preparations, and in spiked urine and serum samples with reliable recovery values