الفهرس 
Title : Study of assessment of 24 hydroxylase activity in children with CKD
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Abstract
Background:Chronic kidney disease (CKD) is a state of stagnant vitamin D metabolism. Assessment of CYP24A1 (mitochondrial enzyme)couldreflects vitamin D catabolism. We aimed toevaluateCYP24A1 activity by assessment of serum 24 hydroxylase level in children with CKD. Method: Prospective cross sectional study included 60 CKD patients and 27 healthy controls.Demographic,clinicaland laboratory data as for CKD patients were reviewed. Serum 24 hydroxylase levels were assessed by sandwich ELISA technique for patients and controls. Results:Serum 24 hydroxylase level was lower in CKD patients than healthy controls but this difference did not reach the statistical significance ((962±703.7 pg/ml versus 1044±352.5 pg/ml with p=0.08). No significant difference between 24 hydroxylase levels of patients with different CKD stages (p=0.184). Serum 24 hydroxylase level positively correlated with serum BUN (p=0.002/correlation coefficient= 0.391), serum creatinine (p=0.007/Correlation coefficient=0.347) and CKD stage (p=0.020/correlation coefficient=0.301) and negatively correlated with GFR (p=0.001/correlation coefficient =-0.424). No significant correlations were found between 24 hydroxylase activity and any of serum calcium, phosphorus ,ALPor parathorm one(p = 0.549, 0.884,0.318 &0.391 respectively)