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Abstract Aim: This experimental randomized study was done to determine and compare the effect of upper limbs resisted exercise versus lower limbs resisted exercise on glycated hemoglobin and nitric oxide in diabetic patients type 2. Subjects: Sixty diabetic patients of both genders (42 males & 18 females) were selected from the outpatient clinic of Internal Medicine department in Agouza Police Hospital. The patient’s age ranged between 50 to 60 years. They were assigned into two groups equal in number. group (A) who received a program of upper limbs resisted exercise (60-75% one repetition maximum), group (B) who received a program of lower limbs resisted exercise (60-75% one repetition maximum). The treatment program continued for 12 weeks (3 sessions of exercise per week). Six minute walk test and laboratory investigations for (glycated hemoglobin and nitric oxide) were measured before the beginning and after 12 weeks of the exercise program for all patients of the two groups. Results: a significant increase in six-minute walk test (3.42%, 6.07%) and nitric oxide (44.61%, 21.53%) and a significant decrease in glycated hemoglobin (10.52%, 7.62%) in both groups respectively. There is no significant difference between group (A) and group (B) in improving six-minute walk test. There is a significant decrease in glycated hemoglobin and a significant increase in nitric oxide in group (A) than group (B) |