الفهرس 
Nucleoside analogsOnly 14 pages are availabe for public view
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Abstract
Acyclic nucleoside analogs exhibited a broad spectrum of antiviral and anticancer activities because of their ability to undergo intracellular phosphorylation to the diphosphate forms and to be incorporated in the growing nucleic acid strand. Phosphoramidates as cytotoxic agents have originated both from the development of more innovative compounds with widespread applicability to familiar cancers and from an understanding of their mechanisms of action, allowing pharmacological intervention to potentiate the antitumor effects of these compounds. Besides, acridinedione moiety which incorporated in the molecule exhibited antiviral and anticancer activities because acridine and related derivatives intercalated with DNA and RNA. Moreover, acridinedione as modified nucleobase is a highly important class of organic compounds, since it possesses a wide range of pharmaceutical and biological activities such as a positive ionotropic effect promoting the entry of calcium to the intracellular space, enzyme and tumor cell inhibition, antimicrobial activity and cytotoxicity.