الفهرس 
Clinical and pathological hallmarks of PD:
Protein deglycase (DJ-1)Only 14 pages are availabe for public view
 |  | from | 265 |  |  |
| | | from | 265 | | |
Abstract
Parkinson’s disease (PD) is a chronic neurodegenerative disease. Unfortunately, the effectiveness of anti-Parkinson treatments gradually diminishes owing to the progressive degeneration of the dopaminergic terminals. The aim of this study was to investigate the effect of BM-MSCs derived exosomes in Parkinson’s disease< induced in rats. Thereby, to determine their potential utility for
neurogenic repair and functional restoration. Methods: The study
was conducted on 40 male albino rats divided randomly into 4 equal groups as follows: healthy control group (І); PD group (II); PDlevodopa group (III) and PD BM-MSCs derived exosomes group
(IV). Behavioral tests were carried out before, after rotenone injections and at the end of the treatment and brain tissue samples were processed for histopathological examination & immunohistochemistry examination for tyrosine hydroxylase enzyme. Brain tissue levels of α-SYN, DJ-1, and PARKIN proteins were measured by ELISA. Genetic expression of circRNA.2837 and miR-34b was
assessed using qRT-PCR. Results: rotenone injection induced pronounced motor deficits, as well as neuronal alterations. The treated groups (III, IV) showed improvement in motor function and brain microscopic picture, also decreased α-SYN and increased DJ-1
and Parkin protein levels compared to PD group II. PD BM-MSCs
derived exosomes group (IV) showed increased level of miR-34b
and slightly decreased level of circRNA.2837 compared to PDL.dopa group (III) and PD group (II).Conclusion: MSC derived
exosomes reduced neuronal degeneration more efficiently than did the anti-Parkinson drug in a rat model of Parkinsonism.