الفهرس 
Subjects and methodsOnly 14 pages are availabe for public view
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Abstract
Background: bronchial asthma and its prevalence in Egypt and worldwide, relationship between bronchial asthma and chemokine receptor 3 gene polymorphism. The aim of the work: Estimate the prevalence of asthma among school-aged children. Estimate the prevalence of various symptom-based clinical phenotypes of asthma. Study the possible environmental determinants of asthma among school-aged children. Describe the pattern of therapy and asthma management among school-aged children. Explore the association between the underlying gene polymorphisms in chemokine receptor 3 (CCR3) and symptom-based clinical asthma phenotypes among the studied group. Type of study: cross sectional study and case control study. Materials and Methods: cross sectional study using modified form ISSAC questionnaire, another case control study to evaluate association of CCR3 gene polymorphism CCR3 T51C and bronchial asthma. Results: prevalence of bronchial asthma in El-Mahalla city was found to be 11.8% in year 2019-2021, there was no significant association found between chemokine receptor 3 gene polymorphism and bronchial asthma. Conclusion: prevalence of bronchial asthma in El-Mahalla city is increasing due to risk factors that is affecting disease development, we could not find any association between chemokine receptor 3 polymorphism among Egyptian children. Recommendations: •In the era of personalized medicine, identifying individual risk factors for each clinical phenotype and tailoring specific preventive measures is warranted. •Developing a national asthma education and prevention program is essential to raise awareness among patients, caregivers and health professionals.