الفهرس 
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Abstract
Many different mediators have been implicated in asthma and they may have a variety of effects on the airways which could account for all of the pathological features of allergic diseases.
In current study tried to assess OPN level in children with bronchial asthma and to determine the relation between OPN and severity of bronchial asthma in Pulmonology unit Pediatric department of Zagazig University.
Our study carried out on 190 children divided into 2 age groups ≤ 5 years
and > 5 years. Each age group divided into 5 subgroups according to different
severities of asthma into intermittent, mild, moderate and severe persistant
asthma with healthy control group.
Pulmonary function tests and serum OPN level were done for patients and controls.
In the current study we found that there was no significant difference between the studied groups as regard baseline data.
There is no significant difference between the studied groups as regard ALT and AST levels, creatinine or Hemoglobin.
There was high significant Positive correlation between Osteopontin and S. IgE and AEC, also there is high significant negative correlation between Osteopontin and FEV1, FVC and PEF in both age groups.
There was significant difference between <5 years severe asthma
and 5-12 years severe asthma as regard Osteopontin level.