الفهرس 
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Abstract
Transient Tachypnea of Newborn (TTN): results from failure of the newborn to effectively clear the fetal lung fluid soon after birth. TTN represents the most common etiology of respiratory distress in term gestation newborns and sometimes requires admission to the neonatal intensive care unit. TTN can lead to maternal-infant separation, the need for respiratory support, extended unnecessary exposure to antibiotics and prolonged hospital stays. Recent evidence also suggests that TTN may be associated with wheezing syndromes later in childhood. New imaging modalities such as lung ultrasound can help in the diagnosis of TTN and early management with distending pressure using continuous positive airway pressure may prevent exacerbation of respiratory distress.
Ischemia-modified albumin (IMA) is a metabolic variant of protein generated during acute ischemic conditions due to a decrease in binding capacity of albumin for transition metals; it is approximately 1% to 2% of the total albumin concentration and increases to 6% to 8% in patients experiencing ischemia. During acute ischemic conditions, the metal binding capacity of albumin for transition metals such as copper, nickel, and cobalt is altered, producing a metabolic variant of the protein, commonly known as IMA.
Aim of the study: To evaluate the diagnostic and prognostic role of ischemia-modified albumin (IMA) levels in infants with transient tachypnea of the newborn (TTN).
Our case control study was conducted on Eighty eight, (88) fullterm neonates: 44(case) (group 1) diagnosed as TTN and 44 (control) (group 2) healthy newborns.
Then the case group is subdivided into two groups:
group 1a managed with Nasal O2 (n=28)
group 1b managed with CPAP (n=16)
All children were subjected to 1- Full maternal and perinatal history 2- Clinical examination 3-Laboratory investigation:
− Routine lab: CBC, CRP, Liver function tests, Kidney function tests, ABG, Electrolytes (Na, K, Ca), Serum Albumin.
− Specific lab: IMA
− Radiological: chest x-ray
During 1st 24hours of neonatal life, blood samples were collected in 2 mL for IMA measurement.
The results of the current study showed:
1. There was higher significant levels of IMA in Case of TTN in compared to control group.
2. There was higher significant levels of IMA in in cases managed with nasal CPAP compared to managed with nasal O2.
3. There was significant higher maternal age in cases with TTN.
4. Levels of IMA were higher in cases needed respiratory support >3 days than those needed ≤ 3 days.
5. There was a negative correlation between IMA and serum albumin however this correlation was non significant.