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Abstract Management of colorectal diseases in the emergency setting, impose a challenge and is associated with high incidence of perioperative mortality and morbidity. Many factors may contribute to this adverse outcome, it may be patient related factors, oncology related or related to presenting derangement locally or systemically. The aim is to study the factors contributing to the high rate of reported morbidity and mortality in colorectal emergencies, with the primary objective of finding a modifiable factor to improve outcome. One hundred thirty seven patients were included in this study (72 non-oncological and 65 oncology related). Comparison between two groups was conducted and statistically significant difference was found in age, site of lesions, percent of patients presenting with hemodynamic instability, frequency of presentation, as well as distribution of more prolonged operative intervention. We found that oncology related etiology per se is an independent factor affecting mortality in multivariate analysis, as well as the patient prior co-morbidity. The two independent modifiable variables were the hemodynamic instability after initial resuscitation and the operative intervention choice. We recommend that the aforementioned factors are included in a scoring system that would be an index for optimization of management to improve outcome. Maximization of pre-operative resuscitative efforts involving experienced anesthesia and surgery consultants is absolutely mandatory. Undue expeditious initiation of definitive surgical treatment before adequate resuscitation might have adverse effects on patients{u2019} mortality as evidenced by our results |