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Abstract
This study was designed to compare the effect of dexmedetomidine on REE in relation to the midazolam in critically ill patients using indirect calorimetry. Thirty critically ill, mechanically ventilated patients received the study drug within 24 hours after intubation. group I patients had DEX (0.075 æg/kg/mL) and group II patients had midazolam (0.5 mg/mL). Both drugs were prepared in 0.9% sodium chloride in 50-mL syringe indistinguishable from one another. Both the agents were titrated to maintain the RASS in a range of {u2212}3 to {u2212}1. DEX infusion was started at 0.15 æg/kg/hr (2 mL/hr) and was adjusted by 0.15 æg/kg/hr increments to a maximum of 0.75 æg/kg/hr, while midazolam was started at 1 mg/hr (2 mL/hr) and was adjusted by 1 mg/hr to a maximum of 5 mg/hr. The metabolic parameters (REE, VO2), the biochemical markers (Plasma interleukin-1Ý, plasma tumor necrosis factor alpha, Plasma catecholamine), the hemodynamic data, and Richmond Agitation-Sedation Score, were reported at predetermined time assessment points. Also patient characteristics, total dose of infused drug, and the time to extubation were reported