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Abstract
Background: The aim of the work is to investigate the effects of dexmedetomidine infusion on oxygenation and lung mechanics in morbidly obese patients with restrictive lung disease. Methods: Forty-two morbidly obese patients scheduled to bariatric surgery were included in the study. Patients were randomized to receive either dexmedetomidine infusion (Dexmedetomidine group) or normal saline infusion (Control group). Both groups were compared with regard to: oxygenation {P/F ratio: PaO2/fraction of inspired oxygen (FiO2)}, lung compliance, dead space, plateau pressure, blood pressure, and heart rate. Results: Dexmedetomidine group showed improved both oxygenation and lung compliance compared to control group by the end of drug infusion. Dexmedetomidine showed also decreased dead space, plateau pressure, blood pressure, and heart rate compared to control group by the end of drug infusion. Conclusion: Dexmedetomidine infusion improved both oxygenation, and lung mechanics in morbidly obese patients with restrictive lung disease