الفهرس 
Modulatory effect of chickpea (Cicer arietinum L.) extract against gamma irradiation in male rats
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Abstract
Ionized radiations trigger risks of serious adverse effects through multiple organ dysfunctions. Administration of natural agents has been suggested to protect against ionizing radiation-induced tissue injury. Thus, the present study was designed to study the ameliorative effect of Cicer arietinum extract (CAE) against whole body Þ-irradiation in male albino rats. In vitro, antioxidant potency of CEA was assessed by ferric reducing antioxidant power (FRAP), hydrogen peroxide (H₂O₂), superoxide radical (O₂.-). Rats (n=24) were divided into control, CAE (500 mg/kg b.wt, p.o) and Þ-irradiated rats; the last exposed to a dose of 6Gy ¹³⁷Cs and subdivided into two subgroups. (1) Þ- irradiated group received vehicle, (2) Þ-irradiated group treated with CAE (500 mg/kg b.wt, p.o). In vitro study revealed that CAE has antioxidant activity. This manifested by its reducing power, its ability to inhibit superoxide radicals (O₂.-), and its ability to quench (H₂O₂). In vivo, Þ-irradiation (6Gy) exposure caused significant increase in the concentration of serum AST, ALT, ÞGT, ALP, creatinine, urea, and uric acid parallel with significant increase in MDA and H₂O₂. Further, Þ-irradiation induced significant decline in the content of GSH, SOD, CAT, and GPx in liver, kidney, and bone. Further, Þ-irradiation induced remarkable change in the serum and tissues trace elements (Ca, Ph, Zn, Fe, Cu) concentration. Additionally, Þ-irradiation exposure provoked significant reduction in the cortical thickness value. On the other hand, CAE (500 mg/kg b.wt, p.o) administration for 21 days to Þ-irradiated rats resulted in an obvious improvement in most of the abovementioned parameters in comparison with the untreated rats. In conclusion, the present findings suggested that CAE has remarkable radioprotective effect against radiation induced biochemical alterations and this effect may be due to its antioxidant efficacy