الفهرس 
Effect of vitamin D on metabolic abnormalities in adolescent females with classical congenital adrenal hyperplasia
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Abstract
Background: Pubertal females with congenital adrenal hyperplasia are more liable to have metabolic abnormalities such as obesity, hypertension, hyperinsulinemia and insulin resistance due to adrenomedullary dysfunction and long term corticosteroids therapy. Aim of the work: Assessment of effect of vitamin D supplementation on metabolic abnormalities in pubertal females with congenital adrenal hyperplasia. Patients and methods: This study was conducted on 23 pubertal females with congenital adrenal hyperplasia who are following up in the endocrinology clinic of the diabetes endocrine and metabolism pediatric unit (DEMPU) at Abo Elrish children{u2019}s hospital, Cairo university. Anthropometric assessment, clinical examination and laboratory investigations were done before and after vitamin D supplementation for 6 months. Laboratory investigations include serum level of 25 (OH) vitamin D, fasting blood glucose and fasting serum insulin level. Insulin resistance was calculated by HOMA-IR, other insulin indices were also calculated; HOMA-S, HOMA-B and quicki. Results: Serum level of 25hydroxy vitamin D was significantly increased after vitamin D supplementation but had no statistical significant effect on insulin resistance and other insulin indices. Conclusion: The results of the current study did not support our hypothesis and we were unable to find beneficial effects of vitamin D supplementation on insulin resistance and other insulin indices in vitamin D deficient pubertal females with congenital adrenal hyperplasia