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Abstract Vitamin D supplementation in preterm neonates and its relation to immune response is a challenge for all researchers. Vitamin D is considered as a biological immune-modulator in preterm infants. The current study compared high versus low dose vitamin D3 supplementation in preterm neonates regarding the immune response (assessment of T regulatory cells). This study is an essential step towards establishment of an evidence-based recommendation for the appropriate dose of vitamin D3 regarding immune response in preterm infants in Egypt. This prospective study was conducted on 40 preterm neonates (28-33 weeks gestational age) admitted to NICU in El-Monira hospital. Higher level of vitamin D can be detected in groups with supplementation but the difference was statistically insignificant between the two groups. There was a statistically significant difference between groups according to flow cytometric assessment for T regulatory cells (%) after 1 and 4 weeks being higher in group B (800 IU/day) compared to group A (400 IU/day) |