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Abstract The findings of the current study support the need for future investigations of novel neuromodulatory approaches for the treatment of CTS. 1. To assess patients with CTS with persistent pain for evidence of central sensitization. 2. To use the BCTQ in assessment of routine clinical visit for patients with CTS. 3. tDCS is effective option with minimal side effects for management of CTS and should be tried in patients with evidence of central sensitization. 4. Further study to assess the most suitable intensity, numbers of sessions and duration for the best effectiveness and minimal side effect of tDCS in CTS. 5. To maximize and provide sustained analgesic effects, further studies that aim to optimize parameters of noninvasive brain stimulation for CTS, such as equipment type, the intensity and polarity of stimulation and long term follow up, are needed. Furthermore, additional studies are needed to provide deeper insight about the nociceptive mechanisms of tDCS in chronic pain. |