الفهرس 
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Abstract
In the liver; cytokines co-ordinate physiologic processes such as liver growth and regeneration, as well as pathologic processes as inflammation during viral liver disease, liver fibrosis, and cirrhosis.
This study was conducted at Beni-Suef University hospital on children with liver diseases to evaluate serum levels of soluble CD-163 in children with liver diseases and explore its role in disease severity.
This study showed that the serum sCD-163 had a significant role in prediction of the liver problem. The mean sCD-163 for patients with fulminant hepatic failure was 19.8±4.6 and was 17.7±7.2 for patients with chronic hepatitis C. The highest levels were in cases with acute HAV, which was 22.1±6.4.
Regarding the demographic data of the cases under the study, the mean age of children with fulminant hepatic failure was 5.3±3.9 years and all of them were males, and that of children with acute HAV was 5.5±0.8 years with females representing 73.1% of cases. Children with chronic hepatitis C had an average age of 8.3±3.1 years with females representing 60.3%.
Regarding the clinical presentation, abdominal pain was prominent in 75% of cases with fulminant hepatic failure compared to hepatitis A and chronic hepatitis C in which it was prevalent in 30.8% and 4.4% respectively.
By examination, hepatosplenomegaly was detected in 25% of cases with fulminant hepatic failure. In cases with acute HAV, hepatomegaly was in 50% of cases with no splenomegaly in all cases. On the other hand, 76.5% of cases with chronic hepatitis C had hepatomegaly and 47.1% had splenomegaly. 25% of cases with fulminant hepatitis had ascites compared to acute HAV and chronic hepatitis C in which ascites was seen only in 3.85 and 1.5% respectively.
The laboratory results for cases under the study showed that the mean SGOT level for cases with fulminant hepatic failure was 628.3±215.2 and the mean SGPT level was 559.8±221.5. In acute HAV infection, the mean SGOT level was 849.7±452.8 and the mean SGPT level was 943.2±520.5. On the other hand, the average of SGOT for cases with chronic hepatitis C was 50.1±9.9 and for SGPT was 41.2±5.5.