الفهرس 
IRRITABLE BOWEL SYNDROMEOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder characterized by the presence of abdominal pain, bloating and altered bowel habits.
The abnormalities of motility, visceral hypersensitivity, gut microbial alteration and psychological stress contribute to the pathophysiology and etiology of IBS.
It has heterogenous unclear etiologies so it is difficult to identify specific biomarkers and therapeutic targets.
The associations of IBS and its risk gene polymorphisms have been studied by many researchers but Single nucleotide polymorphisms (SNPs) represent the most widespread type of sequence variations in genomes.
It is known to be valuable genetic markers, because it may reveal the evolutionary history and common genetic polymorphisms that explain the hereditary risks for IBS.
The present study was comparative case - control study conducted upon 40 subjects during the period from August 2021 to August 2022 who visited gastroenterology outpatient clinic and blood bank of Ain Shams University Hospitals.
The study population was subjected to:
1. Full detailed history including: age, sex and full medical history with special emphasis on history of any chronic diseases, recurrent infections, current medications, any special habits of medical importance.
2. Thorough clinical examination.
3. Complete blood count (CBC) with differential
4. Erythrocytic sedimentation rate (ESR)
5. C_reactive protein (CRP)
6. Liver enzymes (SGOT/SGPT)
7. Kidney function (S.Creat)
8. Stool analysis
9. IL_10 SNP (rs 1800871) by PCR
10. Pelvi-abdominaL U/S
All laboratory results were within normal range
Pelviabdominal U/S shows normal study except for colonic distention in some cases.
The results showed that IL-10 SNP (rs 1800871) had T/T polymorphisms in cases more than controls.
But there is no significant statistical relationship between IL-10 SNP (rs 1800871) and IBS.