الفهرس 
Clinically Isolated SyndromeOnly 14 pages are availabe for public view
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Abstract
Clinically isolated syndrome (CIS) is a central nervous system demyelinating event isolated in time that is compatible with the possible future development of multiple sclerosis (MS). Early risk stratification for conversion to MS helps with treatment decisions. Magnetic resonance imaging (MRI) is currently the most useful tool to evaluate risk. Cerebrospinal fluid studies and evoked potentials may also be used to assess the likelihood of MS, Aim and objectives; to detect the clinical and radiological factors predicting the transform of CIS into RRMS and affecting the prognosis of patients, Subjects and methods: This was Retrospective cohort study, was conducted at Ain Shams university Hospitals on Egyptian adult with CIS or RRMS patients presented to MS unit with first neurological attack within one year from the study. All patients were monitored for any adverse events during the study as infections, Conclusion; The patients with CIS that initially presented with higher MRI brain lesion number, multiple spinal lesion and positive OCB in their CSF are at higher risk for conversion to RRMS and initiation of disease-modifying therapy should be considered as early as possible to overcome the conversion to CDMS