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Abstract Saturated FAs possess the maximal number of hydrogen atoms, while monounsaturated FAs and polyunsaturated FAs (PUFAs) have one, or two or more, double bonds, respectively. PUFAs can be also subdivided on the basis of the location of the first double bond relative to the methyl terminus of the chain. For example, n-3 and n-6 FAs are two of the most biologically significant PUFA classes and have their first double bond on either the third or sixth carbon from the chain terminus, respectively. The final carbon in the FA chain is also known as the omega carbon, hence the common reference to these FAs as omega-3 or omega-6 PUFAs. Long-chain n-3 and n-6 PUFAs are synthesized from the essential FAs (EFAs) alpha-linolenic acid (ALA) and linoleic acid, respectively. An EFA cannot be made by the body and must be obtained through dietary sources. Animals and humans have the capacity to metabolize EFAs to long-chain derivatives. |