الفهرس 
The role of CXC receptor 4 as a prognostic factor in acute lymphoblastic leukemic patients under the influence of different chemotherapeutic agents
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Abstract
Acute lymphoblastic leukemia (ALL) is a common diagnosed malignancy in children, demonstrated in more than a quarter of all pediatric cancers with the lowest survival rate. Several hematopoietic malignancies, were expressing CXCR4 on malignant cells that signifies that CXCL12/CXCR4 pathway guidance cancer biology and was directing the metastasis of CXCR4+tumor cells to other organs expressing CXCL12 like lymph nodes, bones or liver. CXCR4 encourage tumor vascularization, which may affect the prognosis and the response to therapy. CXCR4 expression is the most common chemokine receptor expressed by cancer cells also CXC4R-CXCL12 axis is essential for the migration of normal cells to the BM microenvironment. Aim of work is to evaluate the CXCR4 expression in de novo ALL patients with control then identify their level at day14 and day 42 after treatment with Total XV protocol, to correlate between their expression and disease prognosis and modify therapeutic targets for ALL. The samples were collected from the outpatient clinic at National cancer Institute (NCI), Cairo university (CU), diagnosed between July 2011 and June 2012. The flowcytometric method was used to determine receptor expression