الفهرس 
Fetal brain / liver volume ratio and umbilical volume flow parameters relative to normal and abnormal human development
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Abstract
The purpose of this study is to determine the value of fetal brain / liver volume ratio and its relationship to fetal circulatory parameters during normal and restricted fetal growth. A cross sectional case control study on 100 singleton asymmetrical intrauterine fetal growth restricted pregnancies. VOCAL was used, which provides a semiautomatic delineation that frequently requires manual adjustments by the operator. VOCAL was selected because requires less time to calculate volumes and acceptable reproducibility. The normal fetal brain / liver volume ratio demonstrated a significant reduction with gestational age (R = - 0.54; P < 0.001). The normal mean standard deviation (SD) fetal brain/liver volume ratio (3.4 +- 0.7) was significantly different (P < 0.001) from the mean fetal brain/liver volume ratio in the SGA group (n = 23) (5.9 +- 1.9). A significant difference existed for mean umbilical venous volume flow between AGA (104.7 +- 26.9 mL / min / kg) and SGA (59.6 +- 22.7 mL / min / kg) fetuses. In the SGA fetus, there was a significant inverse relationship (P < 0.001) between fetal weight related umbilical venous volume flow and fetal brain/liver volume ratio. In a subset of 80 SGA and 20 AGA fetuses matched for gestational age, a significant difference existed for umbilical artery pulsatility index (1.01 +- 0.054 vs. 0.89 +- 0.042), fetal middle cerebral artery pulsatility index (1.52 +- 0.25 vs. 1.05 +- 0.25) and late diastolic flow velocity in the fetal ductus venosus (6.9 +- 14.2 cm/s vs. 23.9 +- 8.8 cm/s), but not for peak systolic, early diastolic and time-averaged velocity in the ductus venosus