الفهرس 
Comparative studies on hepatoprotective agents in rats
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Abstract
This study was designed to investigate the hepatoprotective and antioxidant activities of omega-3, l- carnitine, vitamin c and their combination against acetaminophen-induced hepatotoxicity in rats. Rats were pretreated with omega-3, l-carnitine, vitamin c and their combination for twenty-one days prior to oral ingestion of acetaminophen. Then rats received a single toxic dose of acetaminophen. The obtained results showed that pretreatment with omega-3, l- carnitine, vitamin c and their combination limited the toxic effects of acetaminophen. This study concluded that animals treated with the combination (25 OLV) [25 mg / kg b.wt. p.o. Omega-3 plus 50 mg/kg b.wt. p.o. L- carnitine plus 100 mg / kg b.wt. p.o. Vitamin-C] showed the highest hepatoprotective activity against experimentally induced hepatotoxicity in rats. That appeared in most performed tests ALT, AST, Cholesterol, HDL- cholesterol, LDL- cholesterol, Il-6, TNF-Ü, MDA, NOX, GSH, FTIR, Histopathology and Immunohistochemistry caspase-3 and Bax