الفهرس 
Influence of ?S-globin haplotype on stroke risk as detected by TCD among a cohort of Egyptian children with sickle cell disease
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Abstract
Sickle cell disease (SCD) is an inherited disease of beta globin gene. The ÝS haplotypes are senegal, benin, bantu, cameroon, Arab-Indian and atypical haplotypes. Stroke is a catastrophic complication of SCD and is one of the leading causes of death in both adults and children. In light of paucity of studies on ÝS haplotypes in Egypt, the aim of the present study was to determine ÝS haplotypes in 52 children with SCD and evaluate their influence on clinical and hematological features of SCD and their possible prognostic impact on the development of stroke. Benin / benin was the most prevalent haplotype detected in 50% followed by Benin/Bantu in 30.8% of studied patients. Patients with benin / benin haplotype have higher stroke risk and fairly lower HbF% than non Benin/Benin although statistically insignificant. No statistically significant difference was observed regarding other clinical or laboratory parameters between different ÝS haplotypes. Regular blood transfusion was statistically significantly associated with low stroke risk (p<0.001). This study provides a relevant contribution to our understanding of the anthropological and historical background of the population in Egypt. Other genetic, epigenetic and environmental factors may modulate stroke susceptibility in SCD